Inhaltsverzeichnis |
Prof. Dr. med. Dr. phil. Thomas Grunwald
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Schwerpunkte der wissenschaftlichen und klinischen Tätigkeit
- Allgemeine Epileptologie
- Prächirurgische Epilepsiediagnostik
- Elektroencephalographische Diagnostik
- Psychophysiologie limbischer Hirnstrukturen des Menschen
- Kognitive Filterprozesse (sensory gating)
- Neurobiologische Grunlagen rhetorischer Kommunikation
Kurzbiographie
| seit 2009 | Apl. Professor der Universität Bonn. Senior Research Fellow am HfG-Forschungsinstitut Karlsruhe. |
| seit 2002 | Leitender Arzt der Abteilung für Klinische Neuophysiologie des Schweizerischen Epilepsie-Zentrums Zürich. |
| 2001 | Habilitation für das Lehrgebiet Neurologie |
| 1995-2002 | Oberarzt der Univ.-Klinik für Epileptologie Bonn |
| 1992-1995 | Ass.-Arzt, Univ.-Klinik für Epileptologie Bonn |
| 1992 | Promotion zum Dr. med. |
| 1990-1992 | AiP, Univ.-Klinik f. Neurologie Bonn |
| 1984-1992 | Studium der Humanmedizin an der Universität Bonn |
| 1982-1984 | Wiss. Angestellter an der Abt. f. Sprachstörungen der Rheinischen Landesklinik Bonn |
| 1982 | Promotion zum Dr. phil. |
| 1972-1982 | Studium der Phonetik, Germanistik und Anglistik an den Universitäten Marburg, Edinburgh und Köln |
Veröffentlichungen
a. Monographien und Buchbeiträge
Grunwald Th. (1983) Reduktion und Kompensation als Funktion der Sprechge-schwindigkeit im Deutschen. Hamburg: Buske.
Neumann-Schmidt S, Grunwald Th, Thiemens U. (1994) Symptomatische Therapie und Physiotherapie. In: Dengler R, Zierz S, Jerusalem F. (Hrsg.) Amyotrophe Lateralsklerose. Stuttgart, New York: Thieme, 79-87.
Lehnertz K, Elger CE, Grunwald Th, Heinze HJ. (1994) Intrahippokampale Korrelate der P300. In: Stefan H. (Hrsg.) Epilepsie 93, Berlin: Deutsche Sektion der Internationalen Liga gegen Epilepsie, 228-232.
Elger CE, Grunwald Th, Helmstaedter C, Kurthen M. (1995) Cortical localization of cognitive functions. In: Pedley TA, Meldrum BS (Hrsg) Recent advances in epileptology. Vol 6. Edinburgh, London, Melbourne, New York: Churchill Livingstone, 77-95.
Grunwald Th, Elger CE, Lehnertz K, Helmstaedter C, Heinze HJ, Münte TF, Matzke M, Leonhard C. (1995) Intrakranielle kognitive Potentiale bei Gedächtnisprozessen. In: Lang W, Deecke L, Hopf HC (Hrsg.) Verhandlungen der Deutschen Gesellschaft für Neurologie 9, Topographische Diagnostik des Gehirns. Wien, New York: Springer, 91-94.
Elger CE, Brockhaus, A., Grunwald Th. (1996) Epilepsie und Flugreisen. Anti-epileptika und Zeitumstellung. Wiesbaden: Dt. Univ.-Verl.
Grunwald Th, Kurthen M, Elger CE. (1999) Predicting surgical outcome in epilepsy, how good are we? In: Schmidt D, Schacter SC. (Hrsg.) Epilepsy, problem solving in clinical practice. London, Martin Dunitz Publishers: 399-410.
Effern A, Lehnertz K, Grunwald Th, David P, Elger CE. (2000) Nonlinear filtering in wavelet domain: application to single trial analysis of limbic P300 potenteials. In: Lehnertz K, Arnhold J, Grassberger P, Elger CE, (Hrsg.) Chaos in Brain. Singapore: World Scientific, 305-308.
Grunwald Th, Lehnertz K, Kurthen M, Elger CE. (2000) Event-related potentials in temporal lobe epilepsy. In: Lüders HO. (Hrsg.) Epilepsy Surgery. Philadelphia: Lippincott Raven Publishers, 513-519.
Grunwald Th, Kurthen M, Elger CE. (2002) Panic attacks in a woman with frontal lobe epilepsy. In: Schmidt D, Schachter SC. (Hrsg.) 110 Puzzling Cases of Epilepsy. London: Martin Duntitz, 30-33.
Grunwald Th, Beck H. (2003) Epilepsie und Gedächtnis. Hardware & Software. Nürnberg, Novartis Pharma Verlag.
Grunwald Th (2003) Sprachliches Lernen und synaptische Aktivität im Schläfenlappen des Menschen. In: Müller HM, Rickheit G. (Hrsg) Neurokognition der Sprache. Tübingen Stauffenburg, 287-297.
Grunwald Th, Mothersill I, Krämer G (2003) Stürze. In: Schmitz B, Tettenborn B. (Hrsg) Paroxysmale Störungen in der Neurologie. Heidelberg: Springer, 27-49.
Grunwald Th, Vannucci M (2004) Cognition related potentials in the definition of functional deficit zones. In: Rosenow F, Lüders HO (Hrsg) Presurgical Assesment of the Epilepsies with Clinical Neurophysiology and Funtional Imaging. Handbook of Clinical Neurophysiology, Vol 3. Amsterdam, Boston, Heidelberg: Elsevier.
Grunwald Th, Jokeit H (2005) Epilepsie und Teilleistungsstörungen. Nürnberg: Novartis Pharma Verlag.
Grunwald Th (2006) Nebenwirkungsfreiheit: Nicht alle Anfallsfreiheit ist ohne. In: Baumgartner C, Grunwald Th, Mayer Th (Hrsg.) Der epileptologische Triathlon: Anfallsfreiheit, Nebenwirkungsfreiheit, soziale Freiheit. Nürnberg: Novartis Pharma Verlag.
Grunwald Th (2008) Gehirn und Gedudel. Warum die Fußball-Europameisterschaft das Leben verlängert, der Musikantenstadl aber nicht. Wien, New York: Springer.
Mothersill I, Grunwald Th, Krämer G (2010) Sudden Falls. In: Schmitz B, Tettenborn B. (Hrsg) Paroxysmal Disorders. Cambridge: Cambridge University Press (in press).
b. Aufsätze und Zeitschriftenartikel
Grunwald Th, Elger CE, Lehnertz K, Van Roost D, Heinze HJ. (1995) Alterations of intrahippocampal cognitive potentials in temporal lobe epilepsy. Electroencephalography and Clinical Neurophysiology 95, 53-62.
Elger CE, Grunwald Th, Lehnertz K, Kutas M, Helmstaedter C, Brockhaus A, Van Roost, Heinze HJ. (1997) Human temporal lobe potentials in verbal learning and memory processes. Neuropsychologia 35, 657-668.
Grunwald Th, Lehnertz K, Heinze HJ, Helmstaedter C, Elger CE. (1998) Verbal novelty detection within the human hippocampus proper. Proceedings of the National Academy of Sciences USA 95, 3193-3197.
Grunwald Th, Lehnertz K, Helmstaedter C, Kutas M, Pezer N, Kurthen M, Van Roost D, Elger CE. (1998) Limbic ERPs predict verbal memory after left-sided hippocampectomy. Neuroreport 9, 15, 3375-3378.
Helmstaedter C, Grunwald Th, Lehnertz K, Gleißner U, Schramm J, Elger CE. (1998) Differential involvement of left temporolateral and temporomesial structures in verbal declarative learning and memory, evidence from temporal lobe epilepsy. Brain and Cognition 35, 110-131.
Kurthen M, Grunwald Th, Elger CE. (1998) Will there be a neuroscientific theory of consciousness? Trends in Cognitive Sciences 2, 229-234.
Maurer I., Grunwald Th, Elger CE. (1998) Clozapine treatment of delayed-onset paroxysmal Hemidystonia. Movement Disorders 13, 3, 614-615.
Fernández G, Effern A, Grunwald Th, Pezer N, Lehnertz K, DümpelmannM, Van Roost M, Elger CE (1999) Real-Time Tracking of Memory Formation in the Human Rhinal Cortex and Hippocampus. Science 285, 1582-1585.
Grunwald Th, Beck H, Lehnertz K, Blümcke I, Pezer N, Kurthen K, Fernández G, Van Roost D, Heinze HJ, Kutas M, Elger CE. (1999) Evidence relating human verbal memory to hippocampal NMDA-receptors. Proceedings of the National Academy of Sciences USA 96, 12085-12089.
Grunwald Th, Beck H, Lehnertz K, Blümcke I, Pezer N, Kutas K, Kurthen M, Karakas HM, Van Roost D, Wiestler OD, Elger CE. (1999) Limbic P300s in temporal lobe epilepsy with and without Ammon's horn sclerosis. European Journal of Neuroscience 11, 1899-1906.
Grunwald Th, Lehnertz K, Pezer N, Kurthen M, Van Roost D, Schramm J, Elger CE. (1999) Prediction of postoperative seizure control by hippocampal event-related potentials. Epilepsia 40, 3, 303-306.
Kurthen M, Grunwald Th, Elger CE. (1999) Consciousness as a social construction. Behavioral and Brain Sciences 22, 197-199.
Urbach H, Kurthen M, Klemm E, Grunwald Th, Van Roost D, Linke DB, Biersack HJ, Schramm J, Elger CE. (1999) Amobarbital effects on the posterior hippocampus during the intracarotid amobarbital test. Neurology 52, 1596-1602.
Zentner J, Wolf HK, Helmstaedter C, Grunwald Th, Aliashkevich AF, Wiestler OD, Elger CE, Schramm J. (1999) Clinical relevance of amygdala sclerosis in temporal lobe epilepsy. Journal of Neurosurgery 91, 59-67.
Bien CG, Schulze-Bonhage A, Deckert M, Urbach H, Helmstaedter C, Grunwald Th, Schaller C, Elger CE. (2000) Limbic encephalitis unrelated to neoplasm as a cause of temporal lobe epilepsy. Neurology, 55, 1823-1828.
Effern A, Lehnertz K, Schreiber T, Grunwald Th, David P, Elger CE (2000) Nonlinear denoising of transient signals with application to event-related potentials. Physica D 140, 257-266.
Effern A, Lehnertz K, Fernandez G, Grunwald Th, David P, Elger CE (2000) Single trial analysis of event related potentials: non-linear de-noising with wavelets. Clinical Neurophysiology 111, 2255-2263.
Effern A, Lehnertz K, Grunwald Th, Fernandez G, David P, Elger CE (2000) Time adaptive denoising of single trial event-related potentials in the wavelet domain. (2000) Psychophysiology 37, 859-865.
Schramm J, Kral T, Grunwald Th, Blümcke I (2001) Surgical treatment for neocortical temporal lobe epilepsy: clinical and surgical aspects and seizure outcome. Journal of Neurosurgery 94, 33-42.
Fernández G, Heitkemper P, Grunwald Th, Van Roost D, Urbach H, Pezer N, Lehnertz K, Elger CE. (2001) Inferior temporal stream for word processing with integrated mnemonic function. Human Brain Mapping 14, 251-260.
Fell J, Klaver P, Lehnertz K, Grunwald Th, Schaller C, Elger CE, Fernández G. (2001) Human memory formation is accompanied by rhinal-hippocampal coupling and decoupling. Nature Neuroscience 4, 1259-1264.
Schramm J, Aliashkevich AF, Grunwald Th (2002) Multiple subpial transections: outcome and complications in 20 patients who did not undergo resection. Journal of Neurosurgery 97, 39-47.
Grunwald Th, Beck H, Elger CE. (2002) Bausteine des Gedächtnisses: Untersuchungen der menschlichen Hippokampusfunktion in vivo und in vitro. Neuroforum 3, 114-120.
Fernández G, Klaver P, Fell J, Grunwald Th, Elger CE. (2002) Human declarative memory formation: segregating rhinal and hippocampal contributions. Hippocampus 12, 514-519.
Kral T, Clusmann H, Urbach J, Schramm J, Elger CE, Kurthen M, Grunwald Th. (2002) Preoperative evaluation for epilepsy surgery (Bonn Algorithm). Zentralblatt für Neurochirurgie 63, 106-110.
Kirschstein Th, Fernandez G, Grunwald Th, Pezer N, Urbach H, Blümcke I, Van Roost D, Lehnertz K, Elger CE. (2003) Heterotopias, cortical dysplasias and glioneural tumors participate in cognitive processing in patients with temporal lobe epilepsy. Neuroscience Letters 338, 237-241.
Grunwald Th, Boutros NN, Pezer N, von Oertzen J, Fernández G, Schaller C, Elger CE. (2003) Neuronal substrates of sensory gating within the human brain. Biological Psychiatry 53, 511-519.
Vannucci M, Dietl Th, Pezer N, Viggiano MP, Helmstaedter C, Schaller C, Elger CE, Grunwald Th. (2003) Hippocampal function and visual object processing in temporal lobe epilepsy. Neuroreport 14, 1489-1492.
Grunwald Th, Pezer N, Münte Th, Kurthen M, Lehnertz K, Fernández G, Kutas M, Elger CE (2003) Dissecting out conscious and unconscious memory (sub)processes within the human medial temporal lobe. Neuroimage 20, S139-S145.
Kurthen M, Grunwald Th, Helmstaedter C, Elger CE (2003) The problem of content in embodied memory. Behavioral and Brain Sciences 26, 641-642.
Jokeit H, Grunwald Th (2003) Epilepsie und Gedächtnisbeeinträchtigungen. Zeitschrift für Epileptologie 16, 1-7.
Grunwald Th, Krämer G. (2003) Vagusnerv-Stimulation. Epileptologie 20, 69-74.
Dietl Th, Urbach H, Helmstaedter C, Staedtgen M, Szentkuti A, Grunwald Th, Meyer B, Elger C, Kurthen M. (2004) Persistent severe amnesia due to seizure recurrence after unilateral temporal lobectomy. Epilepsy & Behavior. 5, 394-400.
Trautner P, Dietl Th, Staedtgen M, Mecklinger A, Grunwald Th, Elger CE, Kurthen M. (2004) Recognition of famous faces in the medial temporal lobe: an invasive ERP study. Neurology 63, 1203-1208.
Grunwald Th (2004) Hippokampale kognitive Potentiale. Mitteilungen der Österreichischen Sektion der Internationalen Liga gegen Epilepsie. 4, Sonderheft 1, 27-28.
Fell J, Dietl Th, Grunwald Th, Kurthen M, Klaver P, Trautner P, Schaller C, Elger CE, Fernández G. (2004) Neural bases of cognitive ERPs: more than phase reset. Journal of Cognitive Neuroscience 16, 1595-604.
Hilfiker P, Mothersill IW, Grunwald Th, Krämer G (2004) Mobiles Langzeit-EEG: neue diagnostische Möglichkeiten in der Epileptologie. Aktuelle Neurologie 31, 288-294.
Mothersill I, Grunwald Th, Krämer G (2004) Die Telemetrie in der Epilepsie-Abklärung: Löst Longterm-Monitoring das Ruhe-EEG ab? Geriatrie Praxis 15, 31- 33.
Grunwald Th (2004) Limbische Ereignis-korrelierte Potenziale und hippokampale Gedächtnisprozesse. Epileptologie 21, 71-76.
Fell J, Köhling R, Grunwald Th, Klaver P, Dietl Th., Schaller C, Becker A, Elger CE, Fernández G (2005) Phase locking characteristics of limbic P3 responses in hippocampal sclerosis. Neuroimage 24, 980-989.
Dietl T, Trautner P, Staedtgen M, Vannuchi M, Mecklinger A, Grunwald Th, Clusmann H, Elger CE, Kurthen K. (2005) Processing of famous faces and medial temporal lobe event-related potentials: a depth electrode study. Neuroimage 25, 401-407.
Meyer P, Mecklinger A, Grunwald Th, Fell J, Elger CE, Friederici AD (2005) Language processing within the human medial temporal lobes. Hippocampus 15, 451-9.
Boutros NN, Trautner P, Rosburg T, Korzyukov O, Grunwald Th, Schaller C, Elger CE, Kurthen M (2005) Sensory gating in the human hippocampal and rhinal regions. Clinical Neurophysiology 116, 1967-1974.
Schacher M, Haemmerle B, Woermann FG, Okujava M, Huber D, Grunwald Th, Krämer G, Jokeit H (2006) Amygdala fMRI lateralizes temporal lobe epilepsy. Neurology 66, 1-7.*
Vannucci M, Grunwald Th, Pezer N, Dietl T, Helmstaedter C, Schaller C, Viggiano MP, Elger CE. (2006) Hippocampus proper distinguishes between identified and unidentified real-life visual objects: An intracranial ERP study. Neuroscience Letters 401, 165-70.
Boutros NN, Trautner P, Korzyukov O, Grunwald Th, Burroughs S, Elger CE, Kurthen M, Rosburg T (2006) Mid-latency auditory evoked responses and sensory gating in focal epilepsy: a preliminary exploration. Journal of Neuropsychiatry and Clinical Neurosciences 18, 409-416.
Grunwald Th, Kurthen M (2006) Prächirurgische Diagnostik bei mesialer Temporallappenepilepsie. Epileptologie 23, 110-116.
Grunwald Th, Kurthen M (2006) Novelty Detection and Encoding for Declarative Memory within the Human Hippocampus. Clinical EEG and Neuroscience 37, 309-314.
Kurthen M, Grunwald Th (2006) Prädiktoren der kurz- und langfristigen Anfallskontrolle nach resektiver Epilepsiechirurgie. Epileptologie 23, 131-139.
Schacher M, Winkler R, Grunwald Th, Krämer G, Kurthen M, Reed V, Jokeit H (2006) Mesial temporal lobe epilepsy impairs advanced social cognition. Epilepsia 47, 2141-2146.
Kurthen M, Trautner P, Rosburg T, Grunwald Th, Dietl T, Kühn KU, Schaller C, Elger CE, Urbach H, Elisevich K, Boutros NN (2007) Towards a functional topography of sensory gating areas: invasive P50 recording and electrical stimulation mapping in epilepsy surgery candidates. Psychiatry Research 15, 155, 121-133.
Grunwald Th, Ranganath C (2007) The electrophysiology of memory: section II: clinical studies. Exploring human memory processes with event-related potentials. Clin EEG Neurosci 38, 1.
Grunwald Th, Vannucci M, Pezer P, Kurthen M, Schramm J, Elger CE (2007) Gender specific processing of eye contact within the human medial temporal lobe. Clinical EEG and Neuroscience 38, 143-147.
Dietl Th, Kurthen M, Kirch D, Staedtgen M, Schaller C, Elger CE, Grunwald Th (2008) Limbic event-related potentials to words and pictures in the presurgical evaluation of temporal lobe epilepsy. Epilepsy Research 78, 207-215.
Vannucci M, Pezer N, Helmstaedter C, Schaller C,Viggiano MP, Elger CE, Grunwald Th (2008) Hippocampal response to visual objects is related to visual memory functioning. Neuroreport 19, 965-968.
Oppenheim I, Mühlmann H, Blechinger G, Mothersill IW, Hilfiker P, Jokeit H, Kurthen M, Krämer G, Grunwald Th (2009) Brain Electrical Responses to High- and Low-Ranking Buildings. Clinical EEG and Neuroscience 40, 157-161.